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Allergic purpura
Treatment in China

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Condition Guide

About Allergic purpura

Understand the condition, common triggers and treatment options that may require specialist assessment.

Disease Introduction

Allergic purpura (IgA vasculitis) is a vasculitis characterized by the deposition of IgA immune complexes in small blood vessels. It is more common in children and typically presents as symmetrical purpura on the skin. It may be accompanied by joint swelling and pain, abdominal pain, gastrointestinal bleeding, and kidney involvement (IgA vasculitis nephritis). Most cases are self-limiting, but kidney involvement is a key factor affecting long-term prognosis and requires standardized follow-up and management.

Cutting-edge high-precision diagnostic and treatment technologies

KDIGO 2025 Guidelines : The international KDIGO 2025 guidelines systematically standardize the diagnosis and treatment of IgA vasculitis: isolated skin/joint symptoms do not require hormone prophylaxis for nephritis; patients with persistent proteinuria should undergo renal biopsy evaluation.
Precise use of glucocorticoids : Hormones are used for moderate to severe gastrointestinal bleeding, severe abdominal pain, and severe joint swelling and pain. They can shorten the course of abdominal pain and reduce serious complications such as intussusception. Prophylactic use alone is not recommended.
Renal involvement and immunosuppression : IgA vasculitis nephritis is treated according to proteinuria and renal biopsy grading, with prednisone combined with mycophenolate mofetil, azathioprine or cyclophosphamide. Rapidly progressive nephritis is treated according to the severe vasculitis protocol.
Exploration of biological agents : Telitacicept (BLyS/APRIL dual-target fusion protein) showed a significant decrease in proteinuria in the treatment of IgA vasculitis nephritis cases, and B-cell clearance regimens such as rituximab are also being explored.
Plasma exchange for severe cases : In cases of rapidly progressive glomerulonephritis with a large number of crescents or organ damage, plasma exchange can be combined to remove circulating IgA immune complexes, along with high-dose hormones and immunosuppression.

Care Overview

Allergic purpura Treatment in China

The medical team will develop a personalized protocol based on the pathology type, stage, genetic test, previous treatment history, and the patient's physical condition.

1. Observation and support for mild cases : For mild cases without kidney involvement, the main treatment is bed rest, symptomatic pain relief and removal of triggering factors (infection, sensitizing drugs and foods), and most cases can be relieved on their own.
2. Hormone control for severe cases : For patients with severe abdominal pain, gastrointestinal bleeding, or joint swelling and pain, short-term oral or intravenous glucocorticoids should be administered and discontinued as soon as symptoms are relieved.
3. Stratified management of kidney disease : For patients with persistent positive urine protein, renal biopsy should be performed to clarify the pathological grade. Mild to moderate nephritis is treated with hormones ± mycophenolate mofetil, while severe/crescentic nephritis is treated with cyclophosphamide pulse therapy.
4. Long-term follow-up monitoring : Patients with kidney involvement should be followed up for at least 6 to 12 months, with regular urinalysis, quantitative urine protein, and renal function tests to detect and intervene in the progression of chronic kidney disease in a timely manner.
5. Supportive symptomatic treatment : RAS inhibitors are the first choice for patients with hypertension to control blood pressure and reduce proteinuria; SGLT2 inhibitors and other nephroprotective drugs are used for patients with persistent proteinuria or chronic kidney disease.

1. Most cases can heal on their own : IgA vasculitis in children is mostly self-limiting, and with proper supportive treatment, skin rashes and joint symptoms usually subside within a few weeks.
2. Kidney damage is manageable : Guideline-based stratified monitoring and treatment can significantly reduce the risk of progression to chronic kidney disease and kidney failure, and improve long-term prognosis.
3. Effective treatment for severe cases : The combination of hormones, immunosuppression, and plasma exchange can effectively control rapidly progressive glomerulonephritis and critical gastrointestinal complications, reducing mortality.
4. Cutting-edge biological targeting : Dual-target biological agents such as Telitacicept provide new treatment options for patients with hormone-resistant or recurrent diseases, reducing hormone dependence.
5. Comprehensive individualized management : From removing the triggers and controlling symptoms to protecting the kidneys and long-term follow-up, it covers the needs of patients at all stages and balances efficacy and safety.

Network of partner hospitals

Recommended Hospitals

Selected leading medical centers with strong specialties and international patient services.

Institute of Hematology, Chinese Academy of Medical Sciences (Chinese Academy of Medical Sciences Institute of Hematology)

Beijing · Partner Hospital

Institute of Hematology, Chinese Academy of Medical Sciences (Chinese Academy of Medical Sciences Institute of Hematology)

Hematology

The institute is the supporting unit of the National Clinical Research Center for Hematological Diseases, the National Stem Cell Engineering Technology Research Center, and the Stem Cell Medicine Center of the Chinese Academy of Medical Sciences. It is also the executive department of the World Federation of Hemophilia (China), the supporting unit of the National Hemophilia Case Information Management Center, and is leading the establishment of the National Quality Control Center for Hematology. For many consecutive years, it has ranked first in the Fudan University ranking of hematology disciplines, and its CAR-T cell therapy center for hematological diseases ranks second in the country.

Year Founded: 1957
Beds: 1540

Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine

Shanghai · Partner Hospital

Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine

OncologyHematologyGastroenterologyUrologyInternal MedicineSurgeryOrthopedics

Ruijin Hospital consistently ranks among the top four hospitals in China according to the comprehensive hospital rankings released by the Fudan University Hospital Management Institute. It is a national medical center construction unit and possesses national-level platforms such as the National Clinical Research Center for Metabolic Diseases and the National Clinical Research Center for Hematological Diseases. The hospital currently has four key disciplines designated by the Ministry of Education (Hematology, Endocrinology and Metabolic Diseases, Cardiology, and Neurology), 22 national key clinical specialties, and one national key laboratory for medical genomics. The hospital has been awarded the title of National Civilized Unit four times consecutively and has received honors such as the National May 1st Labor Medal and the National Advanced Collective of the Health System. It is also a national demonstration unit for integrated traditional Chinese and Western medicine.

Year Founded: 1907
Beds: 5100

Southern Medical University Southern Hospital

Guangzhou · Partner Hospital

Southern Medical University Southern Hospital

Organ TransplantHematologyInternal MedicineCosmetic Surgery

The hospital is a national regional trauma medical center jointly constructed by the provincial and national governments, a national project unit for improving the diagnosis and treatment capabilities of difficult and complex diseases (tumors), a national regional TCM (rheumatology) treatment center, a national emergency medical rescue base, and one of the first key construction units in Guangdong Province's "Peak Climbing Plan" for high-level hospitals. It boasts 5 national key disciplines, 17 national key clinical specialties, and 4 national key clinical specialty construction projects. In the 2023 national public hospital performance evaluation, it ranked in the A+ category. In authoritative domestic hospital rankings, the hospital consistently ranks among the top 15 to 20 comprehensive hospitals nationwide, with more than ten specialties, including nephrology, infectious diseases, plastic surgery, hematology, pathology, and gastroenterology, ranking in the top ten or receiving nominations.

Year Founded: 1941
Beds: 2225

Union Hospital, Tongji Medical College, Huazhong University of Science and Technology

Wuhan · Partner Hospital

Union Hospital, Tongji Medical College, Huazhong University of Science and Technology

HematologyCardio-CerebrovascularUrology

The hospital ranks 9th nationwide in the Fudan University China Hospital Specialty Ranking, making it one of the strongest hospitals in Central China. Its specialties, including heart transplantation, hematology, ultrasound, nuclear medicine, anesthesiology, and cardiovascular surgery, are among the top in the country. In particular, its nuclear medicine department has consistently ranked among the top two in Fudan University's specialty rankings for many years, and its heart transplant volume has ranked first in the country for many consecutive years. The hospital is a national drug clinical trial institution and a national stem cell clinical research institution, boasting strong research capabilities.

Year Founded: 1866
Beds: 6000

Leading Specialists

Trusted Expertise Across Leading Specialties

Feng Ru

Professor, Chief Physician, Doctoral Supervisor, Deputy Director of Department, Head of Lymphoma Subspecialty

Hematology

-Research areas : pathogenesis, diagnosis and treatment of lymphoma and multiple myeloma, targeted immunotherapy, and leukemia. - Cutting-edge technologies: Dynamic monitoring of MRD for lymphoma and myeloma, and clinical research on new drugs for relapsed and refractory lymphomas. - Areas of expertise: Hodgkin's/non-Hodgkin's lymphoma, multiple myeloma, plasma cell diseases, lymphoma, leukemia. - Academic Highlights & Value: Visiting scholar experience in the United States and Japan; presided over multip

Affiliated Hospital Southern Medical University Southern Hospital

Sun Jing

Professor, Chief Physician, Doctoral Supervisor, Deputy Director of Department, Director of Hemophilia Center

Hematology

-Research areas : Hematopoietic stem cell transplantation, bleeding disorders, and hemophilia diagnosis and treatment - Cutting-edge technologies: unrelated hematopoietic stem cell transplantation, hemophilia inhibitor immune tolerance induction program/comprehensive diagnosis and treatment of hemophilia and inhibitor management (the largest hemophilia center in South China), prevention and treatment of transplant complications. - Areas of expertise: Hemophilia, von Willebrand disease, platelet disorders,

Affiliated Hospital Southern Medical University Southern Hospital

Zhang Xiaobing

Researcher, doctoral supervisor, head of the cell gene transformation platform

Hematology

Research areas : gene editing, CAR vector design, iPSC, LNP delivery technology; Cutting-edge technologies: CRISPR gene editing CAR cells, GMP construction of lentiviral vectors; Areas of expertise: CAR vector development, gene therapy; Academic highlights: National high-level talent, multiple cell therapy invention patents; Core value: Supporting the research and clinical translation of underlying vector technologies for CAR-T and gene therapy.

Affiliated Hospital Institute of Hematology, Chinese Academy of Medical Sciences (Chinese Academy of Medical Sciences Institute of Hematology)

Zhao Weili

Chief Physician, Level 2 Professor, Doctoral Supervisor, Director of Shanghai Institute of Hematology, Vice President of Ruijin Hospital

Hematology

-Research areas : lymphoma immunotherapy, CAR-T cell therapy clinical research, and real-world CAR-T studies in Asian populations. - Cutting-edge technologies: CAR-T stratified treatment system for relapsed and refractory large B-cell lymphoma; CAR-T adverse reaction MDT management model. - Areas of expertise: Diffuse large B-cell lymphoma, primary mediastinal B-cell lymphoma, follicular lymphoma, and other B-cell non-Hodgkin lymphomas. - Academic Highlights: Led a multicenter real-world study of CAR-T th

Affiliated Hospital Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine

Liu Qifa

Level 2 Professor, Chief Physician, Doctoral Supervisor, Academic Leader, Director of the Institute of Hematology

Hematology

Research areas : Molecular pathogenesis of leukemia, hematopoietic stem cell transplantation, tumor immunotherapy, and prevention and treatment of infections in immunocompromised hosts. - Cutting-edge technologies: Haploidentical hematopoietic stem cell transplantation; MICM precision stratification therapy for leukemia; precision stratification therapy for acute leukemia (rewriting the NCCN/ELN guidelines); combined haploidentical and umbilical cord blood transplantation (Lancet RCT); MSC prevention of G

Affiliated Hospital Southern Medical University Southern Hospital

Li Junmin

Head of Hematology

Hematology

Research areas : hematologic malignancies and hematologic immune diseases; construction of CAR-T clinical research system. Cutting-edge technology: creation of translational medicine wards and CAR-T clinical trial screening system. Specializes in treating: acute myeloid leukemia, multiple myeloma, and lymphoma. Academic Highlights: Led the establishment of China's first translational medicine ward in hematology; emphasized that CAR-T "is a novel immunotherapy that acts on the tumor microenvironment and ha

Affiliated Hospital Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine

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OncologyHematology

Patient records Name: Sarah Age: 32 Nationality: Australia Diagnosis: Relapsed/refractory diffuse large B-cell lymphoma (R/R DLBCL), non-germinal center type (non-GCB), CD19 positive, relapsed after autologous stem cell transplantation. Treatment Hospital: Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences (Tianjin) In the field of cancer treatment, CAR-T cell therapy is hailed as "living medicine," bringing hope of a cure to patients with relapsed or refractory hemat

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Allergic purpura
Treatment in China

About Allergic purpura

Allergic purpura Treatment in China

Recommended Hospitals

Institute of Hematology, Chinese Academy of Medical Sciences (Chinese Academy of Medical Sciences Institute of Hematology)

Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine

Southern Medical University Southern Hospital

Union Hospital, Tongji Medical College, Huazhong University of Science and Technology

Trusted Expertise Across Leading Specialties

Feng Ru

Sun Jing

Zhang Xiaobing

Zhao Weili

Liu Qifa

Li Junmin

Chen Saijuan

Pan Jing

Wang Jianxiang

Zhang Ruidong

Wu Runhui

Zhang Rui

Zhai Xiaowen

Shen Shuhong

See the Next Step Through Patient Journeys

Lower Extremity Arteriosclerosis Obliterans - A Masterpiece for Unblocking the "Silent Killer"

Lymphoma : While CAR-T therapy is prohibitively expensive and has long waiting times in the West: An Australian patient found an accessible "cure" in China.

When CAR-T "Failed": How a Singaporean child found a backup plan in China Patient records

A clear, coordinated process for efficient cross-border care

Pre-Visit Services

Remote Consultations

Travel Arrangements

Comprehensive Support in China

Post-Visit Services

Get a Care Plan
and Cost Estimate.

Get a Care Plan and Estimate

Allergic purpuraTreatment in China

Allergic purpura Treatment in China

Recommended Hospitals

Institute of Hematology, Chinese Academy of Medical Sciences (Chinese Academy of Medical Sciences Institute of Hematology)

Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine

Southern Medical University Southern Hospital

Union Hospital, Tongji Medical College, Huazhong University of Science and Technology

Trusted Expertise Across Leading Specialties

See the Next Step Through Patient Journeys

Lower Extremity Arteriosclerosis Obliterans - A Masterpiece for Unblocking the "Silent Killer"

Lymphoma : While CAR-T therapy is prohibitively expensive and has long waiting times in the West: An Australian patient found an accessible "cure" in China.

When CAR-T "Failed": How a Singaporean child found a backup plan in China Patient records

A clear, coordinated process for efficient cross-border care

Pre-Visit Services

Remote Consultations

Travel Arrangements

Comprehensive Support in China

Post-Visit Services

Get a Care Planand Cost Estimate.

Get a Care Plan and Estimate

Allergic purpura
Treatment in China

Get a Care Plan
and Cost Estimate.