Disease Introduction
This is the most common type of malignant skin tumor, including basal cell carcinoma in sun-exposed areas such as the face, squamous cell carcinoma of the skin, and the rare but rapidly progressing Merkel cell carcinoma; most early-stage tumors can be cured by surgical excision, while mid-to-late-stage tumors can be well controlled with immunotherapy.
Cutting-edge high-precision diagnostic and treatment technologies
- Adjuvant Immunotherapy after Squamous Cell Carcinoma Surgery : Cemiplimab (PD-1 monoclonal antibody) was approved by the US FDA in 2025 for adjuvant therapy of squamous cell carcinoma of the skin with a high risk of recurrence after surgery combined with radiotherapy. Phase III studies showed that it reduced the risk of recurrence or death by 68%. It is the first and currently the only approved adjuvant immunotherapy in this field, and it has received a Class 1 preferred recommendation from NCCN (and was also approved by the EU in November 2025).
- Merkel cancer immunotherapy : Avelumab (PD-L1 monoclonal antibody) is the standard first-line immunotherapy for metastatic Merkel cell carcinoma. In the JAVELIN Merkel 200 study, more than one-third of patients achieved objective response. The ADAM Phase III trial in 2025 further confirmed that adjuvant use in patients with postoperative lymph node metastasis can reduce the risk of recurrence.
- BCC Targeting and Sequential Immunotherapy : For locally advanced or metastatic basal cell carcinoma, Hedgehog pathway inhibitors (vemodigine/sonidigine) are used first. If resistance or intolerance occurs, PD-1 immunotherapy such as cimipril can be used to achieve frequent and durable remissions.
- Mohs microscopy : Mohs microscopy examines the surgical margins layer by layer under a microscope during excision. It has a cure rate of up to about 99% for basal cell carcinoma and squamous cell carcinoma in high-risk areas such as the head, face and neck. At the same time, it preserves normal tissue to the greatest extent and takes into account both function and appearance. It is the gold standard surgical procedure for facial skin cancer.
