Disease Introduction
Atopic dermatitis (commonly known as "eczema") is a chronic, recurrent, itchy inflammatory skin disease characterized by dry skin, erythema, papules, and intense itching, often associated with an allergic constitution. The core of treatment is a "step-by-step" approach: mild cases primarily involve topical medications and moisturizers, while moderate to severe cases may benefit from a combination of biologics or oral targeted therapies. Most patients can achieve long-term control.
Cutting-edge high-precision diagnostic and treatment technologies
- Targeted Biologic Agent : Dupilumab (Dapoxetine) targets the IL-4/IL-13 common receptor. It is the first and currently the most widely used biologic agent for moderate to severe atopic dermatitis in China. It is suitable for infants aged 6 months and older, children, adolescents and adults, and has been included in medical insurance.
- Oral JAK inhibitors : Upatinib (Refo) and Abuxitinib (Cervico) are highly selective oral JAK1 inhibitors, one tablet daily, suitable for refractory moderate to severe atopic dermatitis in adolescents aged 12 years and older and adults; Chinese real-world studies such as AHEAD show that the EASI-75 response rate after nearly 1 year of treatment is approximately 76.9%.
- New IL-13 monoclonal antibody : Lereizumab (EBGLYSS) is a specific IL-13 monoclonal antibody. In September 2024, it was approved by the FDA for moderate to severe atopic dermatitis in patients aged 12 years and older. In June 2026, the FDA further approved a maintenance dosing regimen once every 8 weeks. Long-term efficacy data show that about half of the patients achieved complete clearance of skin lesions after 3 years of treatment.
- Roflumilast, a new topical drug : Roflumilast cream (ZORYVE) 0.15% is a topical PDE4 inhibitor. Its marketing authorization application in China was accepted by the NMPA in November 2025. It is intended for the local treatment of mild to moderate atopic dermatitis in children aged 6 years and older, adding a new option for topical non-hormonal treatment.
