liver disease
Treatment in China

Disease Introduction

Liver disease is a broad category of diseases affecting the liver, commonly including viral hepatitis A, B, and C; fatty liver disease caused by long-term alcohol consumption or obesity (now called metabolic-associated fatty liver disease); and drug-induced liver injury caused by medications or health supplements. Early stages are often asymptomatic, but as the disease progresses, symptoms such as fatigue, poor appetite, and jaundice may appear. In the long term, it can develop into liver fibrosis, cirrhosis, and even liver cancer. Treatment generally involves antiviral therapy, metabolic intervention, discontinuation of hepatotoxic drugs, and long-term monitoring of the degree of liver fibrosis.

Cutting-edge high-precision diagnostic and treatment technologies

1. Hepatitis C DAA Cure : Oral administration of pan-genotypic direct-acting antiviral drugs (sofosbuvir, velpatasvir, etc.) for 12 weeks with a sustained virological response rate of over 95% can be considered a clinical cure;
2. Hepatitis B cure under development : Research on functional cures targeting the elimination of hepatitis B surface antigen using new drugs such as small interfering RNA and antisense oligonucleotides in combination with therapeutic vaccines is progressing and is still in the clinical trial stage;
3. GLP-1 for MASH : The Phase III Essence study of semaglutide 2.4mg weekly formulation showed a 62.9% remission rate in metabolic-associated steatohepatitis after 72 weeks. It is expected to be approved by the US FDA in 2025 for MASH with liver fibrosis.
4. Non-invasive liver fibrosis assessment : FibroScan vibration-controlled transient elastography measures liver stiffness and steatosis parameters non-invasively in about 4 minutes, avoiding liver biopsy;
5. Low resistance to TAF/TMF : The 2022 Chinese Guidelines for the Prevention and Treatment of Chronic Hepatitis B listed emitenofovir as a first-line treatment, and the resistance rate of entecavir and tenofovir is extremely low with long-term treatment.