Medical Care in China

Giant cell tumor of bone
Treatment in China

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Trauma treatmentcovers complex fractures and severe limb injuries.
Precision spinal treatmentcovers cervical and lumbar spine diseases and spinal injuries.
Joint function reconstructioncovers joint replacement and complex revision.
Sports medicine techniquesprovide treatment for ligament, meniscus, and cartilage injuries.

Condition Guide

About Giant cell tumor of bone

Understand the condition, common triggers and treatment options that may require specialist assessment.

Disease Introduction

Giant cell tumor of bone is a locally invasive tumor that commonly occurs in the distal ends of long bones (such as the distal femur and proximal tibia) in young adults aged 20-40. It is characterized by osteolytic destruction and is prone to recurrence after surgery. A small number of cases may metastasize to the lungs or become malignant. The advent of RANKL inhibitor drugs has made it possible to control the disease in patients who were previously difficult to operate on.


Cutting-edge high-precision diagnostic and treatment technologies

  1. Denosumab under medical insurance : The RANKL inhibitor denosumab (Angave) was approved in China in May 2019 for the treatment of giant cell tumors of bone that are unresectable or whose surgery would result in severe functional impairment. In July 2020, Professor Niu Xiaohui of Beijing Jishuitan Hospital issued the first prescription in the country. The drug has passed the national medical insurance negotiation and was renewed for inclusion in medical insurance in 2022 (limited to indications such as giant cell tumors of bone), which has significantly reduced the annual treatment cost for patients.
  2. Launch of domestically produced new drugs : Narusobaimab (trade name Jinlisheng), a domestically produced anti-RANKL monoclonal antibody developed by CSPC Pharmaceutical Group (Shanghai Jinmante), was conditionally approved for marketing by the National Medical Products Administration in September 2023 for adult patients with unresectable or surgically operated giant cell tumors of bone, and was submitted for inclusion in the National Reimbursement Drug List in 2026.
  3. Extended curettage and reconstruction : Extended curettage of the lesion + high-speed burr grinding of the capsule wall + bone cement or bone graft filling is the mainstream joint-preserving procedure; a study of 214 cases showed that the combined use of burr, hydrogen peroxide and bone cement reduced the risk of recurrence by about 28 times compared with simple curettage, and the recurrence rate of the systematic review of cases around the knee joint was about 7.1%.
  4. 3D-printed prosthesis reconstruction : For large bone defects after resection, 3D-printed personalized prostheses (such as those for resection of giant cell tumors of the distal radius and periacetabulum) can achieve satisfactory oncological and functional results; the Department of Bone Tumors of Beijing Jishuitan Hospital, as the leading unit, compiled the "CSCO Guidelines for the Diagnosis and Treatment of Giant Cell Tumors of Bone" to standardize diagnosis and treatment nationwide.

Care Overview

Giant cell tumor of bone Treatment in China

The medical team will develop a personalized protocol based on the pathology type, stage, genetic test, previous treatment history, and the patient's physical condition.

Leading Specialists

Trusted Expertise Across Leading Specialties

Zhou Kai

Level 4 Expert

Orthopedics

Research areas: Arthroscopic minimally invasive treatment of acute and chronic sports injuries, surgical treatment of developmental abnormalities/deformities in adolescents, and novel formulations/biological therapies for degenerative diseases. Academic Highlights: Published over 40 papers as first/corresponding author, with the highest single-paper citation count exceeding 260. Research findings were cited as annual research progress by the internationally authoritative academic organization OARSI.

West China Hospital of Sichuan University logo Affiliated Hospital West China Hospital of Sichuan University
Zhang Xianlong

Chief Physician, Level 2 Professor, Doctoral Supervisor, Head of Joint Surgery Department, Director of Robotic Clinical Application Training Center

Orthopedics

-Research areas : robotic joint replacement, complex hip and knee replacement, artificial joint revision, periprosthetic infection. - Cutting-edge technologies: China's first batch of robotic hip/knee/unicompartmental replacements; high dislocation DDH hip replacement; second-stage revision surgery for prosthesis infection. - Areas of expertise: congenital hip dysplasia, femoral head necrosis, severe osteoarthritis, rheumatoid arthritis, ankylosing spondylitis; prosthesis loosening, periprosthetic fractur

Shanghai Jiao Tong University School of Medicine Affiliated Sixth People's Hospital logo Affiliated Hospital Shanghai Jiao Tong University School of Medicine Affiliated Sixth People's Hospital
Yang Qingcheng

Chief Physician, Doctoral Supervisor, Director of Bone Tumor and Bone Disease Surgery

Orthopedics

Research areas : malignant tumors of bone and soft tissue, pelvic and sacral tumors, and complex bone diseases; cutting-edge technologies: 3D-printed tumor prosthesis reconstruction and pelvic and sacral tumor resection and reconstruction. Areas of expertise: osteosarcoma, chondrosarcoma, pelvic and sacral tumors, metastatic bone tumors; Academic highlights: Head of the Shanghai Bone and Soft Tissue Tumor Diagnosis and Treatment Center, Deputy Leader of the Bone Tumor Group of the Chinese Anti-Cancer Asso

Shanghai Jiao Tong University School of Medicine Affiliated Sixth People's Hospital logo Affiliated Hospital Shanghai Jiao Tong University School of Medicine Affiliated Sixth People's Hospital
Peng Xiaochun

Associate Chief Physician, Doctoral Supervisor, Deputy Director of the Department of Joint Surgery

Orthopedics

-Research areas : Aseptic loosening of joint prostheses, biomaterial transformation for osteoarthritis, and minimally invasive joint replacement. - Cutting-edge technologies: minimally invasive small-incision hip and knee replacement; biotherapy for osteoarthritis; research on prosthesis-osseous integration. - Areas of expertise: osteoarthritis of the hip and knee, avascular necrosis of the femoral head, developmental dysplasia of the hip; postoperative rehabilitation management after joint replacement su

Shanghai Jiao Tong University School of Medicine Affiliated Sixth People's Hospital logo Affiliated Hospital Shanghai Jiao Tong University School of Medicine Affiliated Sixth People's Hospital
Zhang Jianguo

Professor , specializing in early-onset scoliosis and hemivertebrae

Orthopedics

Research areas: Clinical treatment and research of early-onset severe spinal deformities, and degenerative spinal diseases. Cutting-edge technology: The clinic pioneered the "short-segment osteotomy fusion combined with dual growth rod technology" for the treatment of severe early-onset scoliosis, and has published over 40 papers. It has completed over 4,000 spinal correction surgeries, treating approximately 200 cases of spinal deformities, and has established the world's largest single-center database o

Peking Union Medical College Hospital, Chinese Academy of Medical Sciences logo Affiliated Hospital Peking Union Medical College Hospital, Chinese Academy of Medical Sciences
Zhang Ke

Professor, Chief Physician (former head of the Joint Group)

Orthopedics

Research areas : hip joint diseases, developmental dysplasia of the hip, hip and knee replacement; cutting-edge technologies: primary replacement of complex DDH, biomechanical research of joint prostheses; Areas of expertise: Congenital hip dysplasia, avascular necrosis of the femoral head, and advanced osteoarthritis of the hip and knee; Academic highlights: A leading expert in complex hip replacement surgery in China, promoting the standardization and popularization of joint replacement in the country;

Peking University Third Hospital (PKU Third Affiliated Hospital) logo Affiliated Hospital Peking University Third Hospital (PKU Third Affiliated Hospital)

Patient Stories

See the Next Step Through Patient Journeys

Congenital Right Radial Paraaxial Hemilimb Deformity - Reshaping the Wings of a CASE 01
PATIENT JOURNEY

Congenital Right Radial Paraaxial Hemilimb Deformity - Reshaping the Wings of a "Fallen Angel" - A Dual Reconstruction of Structure and Function

OrthopedicsPediatrics

Patient records: Name: Dara Age: 5 years old Nationality: Cambodia Diagnosis: Congenital right radial paraaxial hemilimb deformity (congenital limb malformation) Treatment Hospital: Beijing Children's Hospital (Orthopedics), Capital Medical University From "no thumb" to "regaining syndesmosis," we've given wings to angels. Five-year-old Dara is from Phnom Penh, Cambodia. She's a cheerful girl, but she was born without a right thumb. Her right hand resembles a small fork, with only four fingers, making it

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Congenital Scoliosis - Unshackled by the CASE 02
PATIENT JOURNEY

Congenital Scoliosis - Unshackled by the "Butterfly Spine," Rebuilding the Pillar of Life

OrthopedicsPediatrics

Patient records: Name: Nguyen Age: 6 years old Nationality: Vietnamese Diagnosis: Congenital scoliosis (hemievertebral malformation) Treatment Hospital: Shanghai Children's Medical Center (National Children's Medical Center), affiliated with Shanghai Jiao Tong University School of Medicine Precise removal of "bad bone" straightens a curved spine. Six-year-old Nguyen Van from Hanoi, Vietnam, was shorter than other children from a young age, and a bulge on his back grew increasingly noticeable. He was afrai

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evere osteoporosis, new compression fracture of L1 vertebra - supporting the CASE 03
PATIENT JOURNEY

evere osteoporosis, new compression fracture of L1 vertebra - supporting the "flattened" spine

Orthopedics

Patient records Name: Maria Garcia Age: 75 Nationality: Philippines (Manila) Diagnosis: Severe osteoporosis, new compression fracture of L1 vertebra (Genant grade 3), accompanied by intractable pain. Treatment Hospital: Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine — Department of Orthopedics/Spinal Surgery Core technology: Percutaneous balloon dilatation kyphoplasty (PKP) In the video sent by Grandma Maria, she is wearing a brightly colored traditional F

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Complete rupture of the right anterior cruciate ligament combined with a bucket-handle tear of the medial meniscus - Repairing the CASE 04
PATIENT JOURNEY

Complete rupture of the right anterior cruciate ligament combined with a bucket-handle tear of the medial meniscus - Repairing the "ruptured" youthful dream

RehabilitationOrthopedics

Patient records Name: Lucas Martin Age: 19 Nationality: France (Lyon) Diagnosis: Complete rupture of the anterior cruciate ligament in the right knee combined with a bucket-handle tear of the medial meniscus. Treatment Hospital: Department of Sports Medicine, Huashan Hospital Affiliated to Fudan University Lucas was a rising star for Lyon's youth football team, dreaming of becoming a professional player. However, during a crucial qualifying match, a sudden stop and change of direction resulted in a loud t

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